
Rapamycin (Sirolimus) — Targeted HCM Therapy
Clinical studies show Rapamycin reduces pathological left ventricular thickening and supports cardiac function in cats with hypertrophic cardiomyopathy (HCM).
Slows HCM progression
Reduces abnormal left ventricular thickening and slows mid-stage progression.
Improves quality of life
Alleviates symptoms like breathlessness and fatigue to help cats stay active.
Molecular, targeted action
Inhibits the mTOR pathway to reduce pathological cardiac hypertrophy.

Results Of The RAPACAT Trial
How Rapamycin Was Proven Effective in Cats with HCM
- Over a 6-month follow-up, untreated cats with subclinical HCM developed significant thickening of the left ventricle.
- Cats with higher levels of NTproBNP, a blood marker of heart disease, showed faster progression of this thickening.
- Intermittent inhibition of mTOR with rapamycin successfully prevented the progression of left ventricular hypertrophy.